Osteoporosis affects more than 40 million people in the United States, mostly women who are menopausal. Pat Collins, D.Ph., is a pharmacist who consults with patients about drug interactions and effects. She wrote this article pointing out the relationship of osteoporosis to some prescription drugs.
Being informed about how prescribed medicines may actually decrease our health is critical – we cannot count on physicians to tell us these facts. If you have been diagnosed with osteoporosis Pat’s article is for you. You can find Pat’s website at http://medadvocate.net/index.asp.
Drug-Induced Osteoporosis (by Pat Collins)
How many times have we even thought that one or more of our medications may induce or cause another problem? Probably, not too often. We should and we need to keep that in mind when odd things start arising. Some medications can cause a decrease in Bone Mineral Density (BMD). Now remember, a lot of us have co-morbid conditions that can contribute to the decrease in BMD as well.
Our bones provide support for movement, protect our vital organs and are the largest repository for calcium and other minerals. 90% of the body’s calcium is in the skeleton. Something that I had forgotten is that bone is constantly being remodeled (process of synthesis and destruction or resorption).
Just an overview – short and sweet
The cycle of bone remodeling occurs in stages, beginning with the formation of osteoclasts, bone resorption (by osteoclasts), a reversal period, bone matrix formations (by osteoblasts), and, finally mineralization of the matrix.
Medications that Decrease Bone Mineral Density:
Gluccorticoids – Dexamethasone, Triamcinolone, Prednisone, Methylprednisolone, Hydrocortisone
Depot Medroxyprogesterone Acetate (Depo- Provera) – an Intramuscular injection administered every 11-13 weeks
Aromatase Inhibitors – Arimidex (Anastrozole), Femara (Letrozole), Aromasin (Exemestane)
Thiazolidinediones – Actos (Pioglitazone), Avandia (Rosiglitazone)
Proton pump Inhibitors – Aciphex (rabeprazole), Dexilant (dexlansoprazole), Nexium (esomeprazole), Prevacid (lansoprazole), Prilosec (omeprazole), Protonix (pantoprazole), Zegrid (omeprazole and sodium bicarbonate)
Loop Diuretics – Demadex (torsemide), Lasix (Furosemide), Bumex (bumetanide)
Cyclosporine(Neoral, Sandimmune, Gengraf)
Antiretroviral – AZT (zidovudine, Retrovir), ddi (didanosine, Videx), 3TC (Epivir, lamivudine), abacavir (Ziagen), efavirenz (Sustiva), ritonivir (Norvir), Iopinavir/Ritonavir (Kaletra), saquinavir (Invirase), raltegravir (Isentress),
This is not a complete list, but it is close.
Why should we care about osteoporosis?
Weakened bones may make it harder to perform everyday tasks, and you could lose some of your independence.
Thanks, Pat, for allowing me to share your article!